製品の概要

  • 製品名Anti-FKBP52 antibody
    FKBP52 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FKBP52
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Rabbit, Guinea pig, Cow, Pig, Chimpanzee, Rhesus monkey, Opossum, Corn, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal residues 1 - 50 of Human FKBP52 (NP_002005.1)

  • ポジティブ・コントロール
    • Human breast, colon, ovarian or prostate carcinomas.

アプリケーション

Our Abpromise guarantee covers the use of ab84536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may optmize staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
    • 組織特異性Widely expressed.
    • 配列類似性Contains 2 PPIase FKBP-type domains.
      Contains 3 TPR repeats.
    • ドメインThe PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
      The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
      The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
    • 翻訳後修飾Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 51 kDa FK506-binding protein antibody
      • 52 kDa FK506 binding protein antibody
      • 52 kDa FK506-binding protein antibody
      • 52 kDa FKBP antibody
      • 59 kDa immunophilin antibody
      • FK506 binding protein 4 antibody
      • FK506-binding protein 4 antibody
      • FKBP 4 antibody
      • FKBP 52 antibody
      • FKBP 59 antibody
      • FKBP-4 antibody
      • FKBP-52 antibody
      • FKBP4 antibody
      • FKBP4_HUMAN antibody
      • FKBP51 antibody
      • FKBP52 protein antibody
      • FKBP59 antibody
      • HBI antibody
      • Hsp 56 antibody
      • HSP binding immunophilin antibody
      • HSP-binding immunophilin antibody
      • Hsp56 antibody
      • Immunophilin FKBP52 antibody
      • N-terminally processed antibody
      • p52 antibody
      • p59 antibody
      • p59 protein antibody
      • Peptidyl prolyl cis trans isomerase antibody
      • Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
      • Peptidylprolyl cis trans isomerase antibody
      • PPIase antibody
      • PPIase FKBP4 antibody
      • Rotamase antibody
      • T cell FK506 binding protein 59kD antibody
      see all

    Anti-FKBP52 antibody 画像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue using 1/500 ab84536, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian carcinoma tissue using 1/500 ab84536, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian carcinoma tissue, using 1/100 ab84536 in conjunction with 1/100 red-fluorescent Goat anti-Rabbit IgG highly cross-adsorbed antibody Hilyte PlusTM 555.
    • Immunohistochemical analysis of Human endometrial tissue, staining FKBP52 with ab84536 at 1/300 dilution. Staining was detected using DAB.

    Anti-FKBP52 antibody (ab84536) 使用論文

    This product has been referenced in:
    • Wang N  et al. Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity. PLoS One 7:e34010 (2012). IHC-P ; Human . Read more (PubMed: 22448285) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"