製品の概要

  • 製品名Anti-FKBP1B antibody
    FKBP1B 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to FKBP1B
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MGVEIETISP GDGRTFPKKG QTCVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF EEGAAQLGPL SPLPICPHPC, corresponding to amino acids 1-81 of Human FKBP1B

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Associates with the ryanodine receptor (RYR-2) in cardiac muscle sarcoplasmic reticulum and may play a unique physiological role in excitation-contraction coupling in cardiac muscle. There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 組織特異性Isoform 1 and isoform 2 are Ubiquitous with highest levels in brain and thymus.
  • 配列類似性Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
    Contains 1 PPIase FKBP-type domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 12.6 kDa FK506-binding protein antibody
    • 12.6 kDa FKBP antibody
    • Calstabin 2 antibody
    • FK506 binding protein 1 like antibody
    • FK506 binding protein 12.6 antibody
    • FK506 binding protein 1B 12.6 kDa antibody
    • FK506 binding protein 1B antibody
    • FK506-binding protein 1B antibody
    • FKB1B_HUMAN antibody
    • FKBP 12.6 antibody
    • FKBP 1B antibody
    • FKBP 1L antibody
    • FKBP 9 antibody
    • FKBP-12.6 antibody
    • FKBP-1B antibody
    • FKBP12.6 antibody
    • Fkbp1b antibody
    • FKBP1L antibody
    • FKBP9 antibody
    • h FKBP 12 antibody
    • h-FKBP-12 antibody
    • Immunophilin FKBP12.6 antibody
    • OTK 4 antibody
    • OTK4 antibody
    • Peptidyl prolyl cis trans isomerase 1B antibody
    • Peptidyl prolyl cis trans isomerase antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP1B antibody
    • PKBP 1L antibody
    • PKBP1L antibody
    • PPIase 1B antibody
    • PPIase antibody
    • PPIase FKBP1B antibody
    • Rotamase 1B antibody
    • Rotamase antibody
    see all

Anti-FKBP1B antibody 画像

  • Western blot against tagged recombinant protein immunogen using ab58075 FKBP1B antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa
  • IHC image of ab58075 staining in human hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab58075, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-FKBP1B antibody (ab58075) 使用論文

ab58075 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"