製品の概要

  • 製品名Anti-FIG4 antibody
    FIG4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FIG4
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog, Monkey
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 135 and 400 of FIG4 (NP_055660)

  • ポジティブ・コントロール
    • HCT116 and HeLa cells

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab97621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 104 kDa.

ターゲット情報

  • 機能The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
  • 関連疾患Defects in FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) [MIM:611228]. CMT4J is a recessive demyelinating, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy.
    Defects in FIG4 are the cause of amyotrophic lateral sclerosis type 11 (ALS11) [MIM:612577]. ALS is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10%.
  • 配列類似性Contains 1 SAC domain.
  • 細胞内局在Endosome membrane. Localization requires VAC14 and PIKFYVE.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 5-bisphosphate 5-phosphatase antibody
    • ALS 11 antibody
    • ALS11 antibody
    • CMT4J antibody
    • dJ249I4. antibody
    • Fig4 antibody
    • FIG4 homolog (S cerevisiae) antibody
    • FIG4 homolog antibody
    • FIG4 homolog SAC domain containing lipid phosphatase antibody
    • FIG4 homolog SAC1 lipid phosphatase domain containing antibody
    • FIG4 homolog, SAC1 lipid phosphatase domain containing (S cerevisiae antibody
    • FIG4_HUMAN antibody
    • KIAA0274 antibody
    • phosphatidylinositol 3 5 bisphosphate 5 phosphatase antibody
    • Phosphatidylinositol 3 antibody
    • Phosphatidylinositol 3,5 bisphosphate 5 phosphatase antibody
    • Polyphosphoinositide phosphatase antibody
    • RP1-249I4.1 antibody
    • SAC 3 antibody
    • Sac domain containing inositol phosphatase 3 antibody
    • SAC domain containing protein 3 antibody
    • SAC domain-containing protein 3 antibody
    • SAC3 antibody
    • YVS antibody
    see all

Anti-FIG4 antibody 画像

  • Anti-FIG4 antibody (ab97621) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size : 104 kDa

Anti-FIG4 antibody (ab97621) 使用論文

ab97621 has not yet been referenced specifically in any publications.

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