Anti-Fibrinogen gamma chain 抗体 (ab86579)


  • 製品名Anti-Fibrinogen gamma chain antibody
    Fibrinogen gamma chain 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Fibrinogen gamma chain
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide (Human) from the C terminus conjugated to KLH.

  • ポジティブ・コントロール
    • NCI-H460 cell line lysate


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Ammonium Sulphate Precipitation
  • 特記事項(精製)This antibody is prepared by Saturated Ammonium Sulfate precipitation followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野


Our Abpromise guarantee covers the use of ab86579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/50 - 1/100. Predicted molecular weight: 52 kDa.
ELISA 1/1000.


  • 機能Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • 関連疾患Defects in FGG are a cause of thrombophilia.
    Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
  • 配列類似性Contains 1 fibrinogen C-terminal domain.
  • ドメインA long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • 翻訳後修飾Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FGG antibody
    • FIBG_HUMAN antibody
    • Fibrinogen gamma chain antibody
    • Fibrinogen gamma polypeptide antibody
    • fibrinogen gamma-b chain antibody
    see all

Anti-Fibrinogen gamma chain antibody 画像

  • Anti-Fibrinogen gamma chain antibody (ab86579) at 1/50 dilution + NCI-H460 cell line lysate at 35 µg

    Predicted band size : 52 kDa
    Observed band size : 52 kDa
    Additional bands at : 36 kDa,70 kDa. We are unsure as to the identity of these extra bands.

Anti-Fibrinogen gamma chain antibody (ab86579) 使用論文

ab86579 has not yet been referenced specifically in any publications.

Product Wall

ab86579 was generated using a synthetic peptide on the C-terminus of the protein. So, for detection methods like Western blot or IHC, the target protein are denatured. Conformational changes would not matter. If you are going to use it to detect native...

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