製品の概要

  • 製品名Anti-Fibrillin 2 antibody
    Fibrillin 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Fibrillin 2
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide: CAGFANRGDVLTGR conjugated to KLH, corresponding to internal sequence amino acids 1055-1067 of Human Fibrillin 2

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53804 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
  • 関連疾患Defects in FBN2 are the cause of congenital contractural arachnodactyly (CCA) [MIM:121050]; also known as Beals syndrome or distal arthrogryposis type 9 (DA9). CCA is a rare, autosomal dominant connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Phenotypically similar to Marfan syndrome, CCA does not affect the aorta and the eyes.
  • 配列類似性Belongs to the fibrillin family.
    Contains 47 EGF-like domains.
    Contains 9 TB (TGF-beta binding) domains.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CCA antibody
    • congenital contractural arachnodactyly (Marfanoid-like) antibody
    • DA9 antibody
    • FBN2 antibody
    • FBN2_HUMAN antibody
    • fibrillin 2 (congenital contractural arachnodactyly) antibody
    • Fibrillin-2 antibody
    see all

Anti-Fibrillin 2 antibody (ab53804) 使用論文

ab53804 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (intevertebral disc)
Specification intevertebral disc
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 6% · Temperature: RT°C
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投稿 Jan 27 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"