製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Fibrillarin
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence around amino acids 297-301 (

    LTLEP

    ) of Human Fibrillarin (NP_001427.2).

  • ポジティブ・コントロール
    • HeLa and 293 cell extracts

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab119396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 33 kDa).

ターゲット情報

  • 機能
    S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
  • 配列類似性
    Belongs to the methyltransferase superfamily. Fibrillarin family.
  • 翻訳後修飾
    By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
  • 細胞内局在
    Nucleus, nucleolus. Fibrillar region of the nucleolus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 34 kD nucleolar scleroderma antigen antibody
    • 34 kDa nucleolar scleroderma antigen antibody
    • Fbl antibody
    • FBRL_HUMAN antibody
    • FIB antibody
    • FIB1 antibody
    • FLRN antibody
    • Histone-glutamine methyltransferase antibody
    • Nop1p antibody
    • RNA U3 small nucleolar interacting protein 1 antibody
    • RNU3IP1 antibody
    • rRNA 2' O methyltransferase fibrillarin antibody
    • rRNA 2'-O-methyltransferase fibrillarin antibody
    see all

画像

  • All lanes : Anti-Fibrillarin antibody (ab119396) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : 293 cell extract

    Predicted band size: 33 kDa

プロトコール

参考文献

ab119396 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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