製品の概要

  • 製品名Anti-FH antibody
    FH 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to FH
  • アプリケーション適用あり: Sandwich ELISA, WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Cow, Dog, Pig, Drosophila melanogaster, Zebrafish, a wide range of other species, Cynomolgus Monkey, Chlamydia trachomatis, Orangutan
  • 免疫原

    Synthetic peptide:

    C-HPNDHVNKSQSSND

    , corresponding to internal sequence amino acids 176-189 of Human FH

  • ポジティブ・コントロール
    • Human Kidney, Liver and Lung lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab62825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Sandwich ELISA Use a concentration of 1 - 2 µg/ml. Used as a reporter to detect recombinant Fumarase
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 55 kDa).
ELISA 1/64000.

ターゲット情報

  • 機能Also acts as a tumor suppressor.
  • パスウェイCarbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • 関連疾患Defects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • 配列類似性Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • 細胞内局在Cytoplasm and Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody 画像

  • Anti-FH antibody (ab62825) at 0.01 µg/ml + Human Kidney lysate in RIPA buffer at 35 µg/ml

    Predicted band size : 55 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)


  • Predicted band size : 55 kDa

Anti-FH antibody (ab62825) 使用論文

This product has been referenced in:
  • Kienhöfer J  et al. Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents. FASEB J 23:2034-44 (2009). WB ; Human . Read more (PubMed: 19228881) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"