製品の概要

  • 製品名
  • 製品の詳細
    Mouse monoclonal to FH
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 33-511 of Human FH

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 22867999

ターゲット情報

  • 機能
    Also acts as a tumor suppressor.
  • パスウェイ
    Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • 関連疾患
    Defects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • 配列類似性
    Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • 細胞内局在
    Cytoplasm and Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody 画像



  • Predicted band size : 55 kDa
    FH antibody (ab58232) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • Immunofluorescence analysis of UOK268 cells, staining FH with ab58232.

    Cells were fixed in formaldehyde and permeabilized with 0.2% Triton X-100. Samples were incubated with primary antibody (1/200) for 1 hour at room temperature. An AlexaFluor®488-conjugated goat anti-mouse IgG (1/500) was used as the secondary antibody.

Anti-FH antibody (ab58232) 使用論文

This product has been referenced in:
  • Perrier-Trudova V  et al. Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2. Anticancer Res 35:6639-53 (2015). Read more (PubMed: 26637880) »
  • Beernink PT  et al. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clin Vaccine Immunol 21:1505-11 (2014). Read more (PubMed: 25185576) »

See all 5 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab58232.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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