Anti-FGFR1 抗体 [EPR806Y] (ab76464)

製品の概要

• 製品名
  Anti-FGFR1 antibody [EPR806Y]
  FGFR1 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR806Y] to FGFR1
• アプリケーション
  適用あり: ICC/IF, WBmore details
  適用なし: IHC-P
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human FGFR1 aa 800 to the C-terminus (C terminal).
  (Peptide available as ab177436)

• ポジティブ･コントロール
  • WB: Wild-type HAP1, MCF-7 and SH-SY5Y cell lysate.
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated "PUR" on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab^® patents

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
• バッファー
  pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
• Concentration information loading...
• 精製度
  Protein A purified
• ポリ/モノ
  モノクローナル
• クローン名
  EPR806Y
• アイソタイプ
  IgG
• 研究分野
  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • FGF
  • FGF Receptors

  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Receptor Tyrosine Kinases

  • Signal Transduction
  • Growth Factors/Hormones
  • FGF

  • Neuroscience
  • Neurology process
  • Neurogenesis

  • Cancer
  • Growth factors
  • FGF

関連製品

• Alternative Products
  • Anti-FGFR1 antibody [EPR806Y] - Low endotoxin, Azide free (ab206382)
• Alternative Versions
  • Anti-FGFR1 antibody [EPR806Y] - Low endotoxin, Azide free (ab206382)
• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • FGFR1 peptide (ab177436)

アプリケーション

ターゲット情報

• 機能
  Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL (By similarity). A shorter form of the receptor could be a receptor for FGF1 (aFGF).
• 組織特異性
  Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
• 関連疾患
  Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
  Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.
  Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.
  Defects in FGFR1 are the cause of trigonocephaly non-syndromic (TRICEPH) [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.
  Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
  Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
  Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
• 配列類似性
  Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
  Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  Contains 1 protein kinase domain.
• 翻訳後修飾
  Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
• 細胞内局在
  Membrane. Nucleus. Cytoplasm. Cytoplasmic vesicle

• Target information above from: UniProt accession P11362 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 2260 Human
  • Omim: 136350 Human
  • SwissProt: P11362 Human
  • Unigene: 264887 Human
• 別名
  • Basic fibroblast growth factor receptor 1 antibody
  • bFGF-R-1 antibody
  • BFGFR antibody

  • CD331 antibody
  • CEK antibody
  • FGFBR antibody
  • FGFR 1 antibody
  • FGFR-1 antibody
  • FGFR1 antibody
  • FGFR1/PLAG1 fusion antibody
  • FGFR1_HUMAN antibody
  • fibroblast growth factor receptor 1 antibody
  • FLG antibody
  • FLT-2 antibody
  • FLT2 antibody
  • Fms-like gene antibody
  • Fms-like tyrosine kinase 2 antibody
  • fms-related tyrosine kinase 2 antibody
  • HBGFR antibody
  • heparin-binding growth factor receptor antibody
  • HH2 antibody
  • HRTFDS antibody
  • hydroxyaryl-protein kinase antibody
  • KAL2 antibody
  • N-SAM antibody
  • OGD antibody
  • Proto-oncogene c-Fgr antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols