Anti-FGF8 抗体 [MM0291-8D24] (ab89550)
Key features and details
- Mouse monoclonal [MM0291-8D24] to FGF8
- Suitable for: IHC-P, WB, Neutralising
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-FGF8 antibody [MM0291-8D24]
FGF8 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MM0291-8D24] to FGF8 -
由来種
Mouse -
アプリケーション
適用あり: IHC-P, WB, Neutralisingmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length Human FGF8 protein.
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ポジティブ・コントロール
- WB: Human placenta tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
ポリ/モノ
モノクローナル -
クローン名
MM0291-8D24 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab89550の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (1) |
Use at an assay dependent concentration.
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WB |
1/500 - 1/1000. Predicted molecular weight: 27 kDa.
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Neutralising |
Use at an assay dependent concentration.
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特記事項 |
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IHC-P
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 27 kDa. |
Neutralising
Use at an assay dependent concentration. |
ターゲット情報
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機能
Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. -
関連疾患
Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. -
配列類似性
Belongs to the heparin-binding growth factors family. -
発生段階
In adults expression is restricted to the gonads. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 2253 Human
- Omim: 600483 Human
- SwissProt: P55075 Human
- Unigene: 57710 Human
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別名
- AIGF antibody
- Androgen induced growth factor antibody
- Androgen-induced growth factor antibody
see all
画像
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Anti-FGF8 antibody [MM0291-8D24] (ab89550) at 1/500 dilution + Human placenta tissue lysate
Predicted band size: 27 kDa
Observed band size: 23 kDa why is the actual band size different from the predicted?
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (0)
ab89550 は論文での使用が確認できていません。