製品の概要

  • 製品名
  • 製品の詳細
    Sheep polyclonal to FGF2
  • 特異性
    Cross reactivity: This antibody is known to react with human, mouse, rat and other rodents. Cross reactivity with other species has not been tested. Specificity was demonstrated by immunohistochemistry.
  • アプリケーション
    適用あり: IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant human basic Fibroblast Growth Factor.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab6209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr
  • 追加情報
    Immunohistochemistry: 1/2,000
    Western Blot: Not tested.
    Immunoblot: Not tested.
    1 site ELISA: Not tested.
    Biological Inhibition: Not tested.
  • ターゲット情報

    • 機能
      Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
    • 組織特異性
      Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
    • 配列類似性
      Belongs to the heparin-binding growth factors family.
    • 翻訳後修飾
      Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
      Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
    • 細胞内局在
      Secreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Basic fibroblast growth factor antibody
      • Basic fibroblast growth factor bFGF antibody
      • BFGF antibody
      • FGF 2 antibody
      • FGF B antibody
      • FGF-2 antibody
      • Fgf2 antibody
      • FGF2 basic antibody
      • FGF2_HUMAN antibody
      • FGFB antibody
      • Fibroblast growth factor 2 (basic) antibody
      • Fibroblast growth factor 2 antibody
      • Fibroblast growth factor, basic antibody
      • HBGF 2 antibody
      • HBGF-2 antibody
      • HBGF2 antibody
      • HBGH 2 antibody
      • HBGH2 antibody
      • Heparin binding growth factor 2 precursor antibody
      • Heparin-binding growth factor 2 antibody
      • Prostatropin antibody
      see all

    プロトコール

    Anti-FGF2 antibody (ab6209) 使用論文

    ab6209 has not yet been referenced specifically in any publications.

    Product Wall

    This antibody basic FGF (sheep) works well in tissues that have been fixed in Zamboni's fixative. This is 15% saturated picric acid in 4% paraformaldehyde in phosphate buffer. Antigen retrieval is not required.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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