Anti-Ferritin Light Chain 抗体 (ab110017)

製品の概要

  • 製品名
    Anti-Ferritin Light Chain antibody
    Ferritin Light Chain 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Ferritin Light Chain
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-GEYLFERLTLKHD

    , corresponding to C terminal amino acids 163-175 of Human Ferritin Light Chain

  • ポジティブ・コントロール
    • Human brain (cortex) tissue, Human kidney tissue, Human placenta lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 20 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

ターゲット情報

  • 機能
    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
  • 関連疾患
    Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
    Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
  • 配列類似性
    Belongs to the ferritin family.
    Contains 1 ferritin-like diiron domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Ferritin L chain antibody
    • Ferritin L subunit antibody
    • Ferritin light chain antibody
    • Ferritin light polypeptide antibody
    • ferritin light polypeptide like 3 antibody
    • FRIL_HUMAN antibody
    • FTL antibody
    • LFTD antibody
    • NBIA 3 antibody
    • NBIA3 antibody
    see all

Anti-Ferritin Light Chain antibody 画像

  • ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human brain (cortex) by immunohistochemistry.
  • ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human kidney tissue by immunohistochemistry.
  • Anti-Ferritin Light Chain antibody (ab110017) at 0.1 µg/ml + Human placenta lysate at 35 µg

    Predicted band size : 20 kDa

Anti-Ferritin Light Chain antibody (ab110017) 使用論文

ab110017 has not yet been referenced specifically in any publications.

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