Anti-Ferritin Light Chain 抗体 (ab110017)
Key features and details
- Goat polyclonal to Ferritin Light Chain
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-Ferritin Light Chain antibody
Ferritin Light Chain 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to Ferritin Light Chain -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig -
免疫原
Synthetic peptide:
C-GEYLFERLTLKHD
, corresponding to C terminal amino acids 163-175 of Human Ferritin Light Chain -
ポジティブ・コントロール
- Human brain (cortex) tissue, Human kidney tissue, Human placenta lysate.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110017の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 20 kDa.
|
|
IHC-P |
Use a concentration of 3.75 µg/ml.
|
特記事項 |
---|
WB
Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 20 kDa. |
IHC-P
Use a concentration of 3.75 µg/ml. |
ターゲット情報
-
機能
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. -
関連疾患
Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. -
配列類似性
Belongs to the ferritin family.
Contains 1 ferritin-like diiron domain. - Information by UniProt
-
参照データベース
- Entrez Gene: 286861 Cow
- Entrez Gene: 477042 Dog
- Entrez Gene: 2512 Human
- Entrez Gene: 14325 Mouse
- Entrez Gene: 29292 Rat
- Omim: 134790 Human
- SwissProt: O46415 Cow
- SwissProt: Q53VB8 Dog
see all -
別名
- Ferritin L chain antibody
- Ferritin L subunit antibody
- Ferritin light chain antibody
see all
画像
-
ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human brain (cortex) by immunohistochemistry.
-
ab110017, at 3.75 µg/ml, staining Ferritin Light Chain in Human kidney tissue by immunohistochemistry.
-
Anti-Ferritin Light Chain antibody (ab110017) at 0.1 µg/ml + Human placenta lysate at 35 µg
Predicted band size: 20 kDa
Primary incubation was 1 hour. Detected by chemiluminescence.
プロトコール
データシートおよび資料
-
Datasheet download
参考文献 (1)
ab110017 は 1 報の論文で使用されています。
- Gal J et al. Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons. J Neuropathol Exp Neurol 77:21-39 (2018). PubMed: 29186589