製品の概要

  • 製品名Fenobam
  • 製品の詳細
    Selective, potent, orally active mGlu5 antagonist
  • 生理活性の詳細Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
  • 精製度> 99%

製品の特性

    Fenobam (ab120034) 使用論文

    This product has been referenced in:
    • Wållberg A  et al. Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues. Bioorg Med Chem Lett 16:1142-5 (2006). Read more (PubMed: 16380255) »
    • Porter RH  et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther 315:711-21 (2005). Read more (PubMed: 16040814) »
    • Goldberg ME  et al. Novel non-benzodiazepine anxiolytics. Neuropharmacology 22:1499-504 (1983). Read more (PubMed: 6142427) »

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