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DINYQDQIPRTLEE, corresponding to amino acids 609-622 of Human FEM 1B(Peptide available as ab6098.)
Fas and Tumor Necrosis Factor Receptor 1 (TNFR 1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR 1 was recently identified and designated F1A alpha and FEM 1 beta. F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM 1. FEM 1/F1Aa is cleaved by CED-3 and caspase. FEM 1/F1Aa associates with CED-4 and its mammalian homologue Apaf 1. Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues.
Our Abpromise guarantee covers the use of ab3686 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 70 kDa.Can be blocked with FEM 1B peptide (ab6098).|
|ICC/IF||Use a concentration of 20 µg/ml.|
|IHC-P||Use a concentration of 5 µg/ml.|
ab3686 at 5µg/ml staining of FEM 1B in mouse liver tissue by IHC
ab3686 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"