製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FDPS
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human FDPS aa 389-419 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: P14324

  • ポジティブ・コントロール
    • WB: Human cytokeratin liver cell lysate, IHC-P: Human hepatocarcinoma tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab38854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 41 kDa).
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能
    Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
  • パスウェイ
    Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
    Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
  • 配列類似性
    Belongs to the FPP/GGPP synthase family.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • (2E antibody
    • (2E,6E) farnesyl diphosphate synthase antibody
    • 6E)-farnesyl diphosphate synthase antibody
    • Dimethylallyltranstransferase antibody
    • Farnesyl diphosphate synthase antibody
    • Farnesyl diphosphate synthetase antibody
    • Farnesyl pyrophosphate synthase antibody
    • Farnesyl pyrophosphate synthetase antibody
    • Fdps antibody
    • FPP synthase antibody
    • FPP synthetase antibody
    • FPPS antibody
    • FPPS_HUMAN antibody
    • FPS antibody
    • Geranyltranstransferase antibody
    see all

画像

  • Anti-FDPS antibody (ab38854) + Human cytokeratin liver cell lysate

    Predicted band size : 41 kDa
    Observed band size : 44 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocarcinoma tissue labelling FDPS with ab38854. A peroxidase-conjugated anti-rabbit IgG was used as the secondary antibody, followed by DAB staining.

参考文献

This product has been referenced in:
  • Mishra S  et al. Accumulation of cholesterol and increased demand for zinc in serum-deprived RPE cells. Mol Vis 22:1387-1404 (2016). WB . Read more (PubMed: 28003730) »
  • Chen GP  et al. Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process. J Diabetes Res 2015:379287 (2015). WB . Read more (PubMed: 25918730) »

See all 6 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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