製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Fbxw7
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region aithin amino acids 50 - 100 of Human Fbxw7 (NP_361014.1)

  • ポジティブ・コントロール
    • Breast carcinoma, O=ovarian carcinoma, pancreatic islet cell tumor, skin melanoma, small cell lung cancer.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
    • 組織特異性
      Isoform 1 is widely expressed. Isoform 4 is expressed in brain.
    • 配列類似性
      Contains 1 F-box domain.
      Contains 7 WD repeats.
    • 翻訳後修飾
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在
      Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AGO antibody
      • Archipelago antibody
      • Archipelago homolog antibody
      • Archipelago, Drosophila, homolog of antibody
      • CDC4 antibody
      • CDC4, S.cerevisiae, homolog of antibody
      • DKFZp686F23254 antibody
      • F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody
      • F box and WD 40 domain protein 7 antibody
      • F box and WD repeat domain containing 7 antibody
      • F box protein FBW7 antibody
      • F box protein FBX30 antibody
      • F box protein SEL 10 antibody
      • F box protein SEL10 antibody
      • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody
      • F-box and WD-40 domain-containing protein 7 antibody
      • F-box protein FBX30 antibody
      • F-box/WD repeat-containing protein 7 antibody
      • FBW6 antibody
      • FBW7 antibody
      • FBX30 antibody
      • FBXO30 antibody
      • FBXW6 antibody
      • FBXW7 antibody
      • FBXW7_HUMAN antibody
      • FLJ16457 antibody
      • hAgo antibody
      • hCdc4 antibody
      • Homolog of C elegans sel 10 antibody
      • Homolog of C.elegans sel10 antibody
      • SEL 10 antibody
      • SEL-10 antibody
      • SEL10 antibody
      see all

    画像

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma, using 1/500 ab84783 followed by DAB staining.

    プロトコール

    参考文献

    ab84783 has not yet been referenced specifically in any publications.

    レビューと Q&A

    Thank you for your phone call yesterday. I have heard back from the production lab, and I was told the following regarding the concentration of ab84783: "We do not have the precise concentration of IgG in this antibody, as the antibody is prepare...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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