Anti-Fbxw7 抗体 (ab84783)
Key features and details
- Rabbit polyclonal to Fbxw7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Fbxw7 antibody
Fbxw7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Fbxw7 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Chimpanzee, Rhesus monkey, Gorilla -
免疫原
Synthetic peptide corresponding to a region aithin amino acids 50 - 100 of Human Fbxw7 (NP_361014.1)
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ポジティブ・コントロール
- Breast carcinoma, O=ovarian carcinoma, pancreatic islet cell tumor, skin melanoma, small cell lung cancer.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: Tris buffered saline, 0.1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab84783の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
特記事項 |
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Note: expected to work on frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. -
組織特異性
Isoform 1 is widely expressed. Isoform 4 is expressed in brain. -
配列類似性
Contains 1 F-box domain.
Contains 7 WD repeats. -
翻訳後修飾
Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 55294 Human
- Omim: 606278 Human
- SwissProt: Q969H0 Human
- Unigene: 561245 Human
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別名
- AGO antibody
- Archipelago antibody
- Archipelago homolog antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab84783 は 2 報の論文で使用されています。
- Liu H et al. Low expression of the ubiquitin ligase FBXW7 correlates with poor prognosis of patients with colorectal cancer. Int J Clin Exp Pathol 11:413-419 (2018). PubMed: 31938126
- Imura S et al. Role of Fbxw7 expression in hepatocellular carcinoma and adjacent non-tumor liver tissue. J Gastroenterol Hepatol 29:1822-9 (2014). PubMed: 24731221