製品の概要

  • 製品名Anti-Fbxw7 antibody
    Fbxw7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Fbxw7
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from the human Fbxw7 protein

  • ポジティブ・コントロール
    • Widely expressed in most human tissues. Human brain lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab81256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 80 kDa.

ターゲット情報

  • 機能Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
  • 組織特異性Isoform 1 is widely expressed. Isoform 4 is expressed in brain.
  • 配列類似性Contains 1 F-box domain.
    Contains 7 WD repeats.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm; Nucleus; Nucleus > nucleolus and Nucleus > nucleoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AGO antibody
    • Archipelago antibody
    • Archipelago homolog antibody
    • Archipelago, Drosophila, homolog of antibody
    • CDC4 antibody
    • CDC4, S.cerevisiae, homolog of antibody
    • DKFZp686F23254 antibody
    • F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody
    • F box and WD 40 domain protein 7 antibody
    • F box and WD repeat domain containing 7 antibody
    • F box protein FBW7 antibody
    • F box protein FBX30 antibody
    • F box protein SEL 10 antibody
    • F box protein SEL10 antibody
    • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody
    • F-box and WD-40 domain-containing protein 7 antibody
    • F-box protein FBX30 antibody
    • F-box/WD repeat-containing protein 7 antibody
    • FBW6 antibody
    • FBW7 antibody
    • FBX30 antibody
    • FBXO30 antibody
    • FBXW6 antibody
    • FBXW7 antibody
    • FBXW7_HUMAN antibody
    • FLJ16457 antibody
    • hAgo antibody
    • hCdc4 antibody
    • Homolog of C elegans sel 10 antibody
    • Homolog of C.elegans sel10 antibody
    • SEL 10 antibody
    • SEL-10 antibody
    • SEL10 antibody
    see all

Anti-Fbxw7 antibody (ab81256) 使用論文

ab81256 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Specification HeLa
Fixative Paraformaldehyde
Permeabilization Yes - 0.5% Triton X100
Username

Dr. Kirk McManus

Verified customer

投稿 Oct 19 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"