製品の概要

  • 製品名Anti-FBXL20 antibody
    FBXL20 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FBXL20
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    An 18 amino acid peptide near the carboxy terminus of human FBXL20.

  • ポジティブ・コントロール
    • A20 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab67232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 44, 48 kDa (predicted molecular weight: 44 , 48 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 関連性FBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
  • 細胞内局在Cytoplasmic
  • 参照データベース
  • 別名
    • F box and leucine rich repeat protein 20 antibody
    • F box/LRR repeat protein 2 like antibody
    • F box/LRR repeat protein 20 antibody
    • Fbl2 antibody
    • Fbl20 antibody
    • MGC15482 antibody
    • SCR antibody
    • SCRAPPER antibody
    see all

Anti-FBXL20 antibody 画像

  • Lane 1 : Anti-FBXL20 antibody (ab67232) at 0.5 µg/ml
    Lane 2 : Anti-FBXL20 antibody (ab67232) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 44 , 48 kDa
    Observed band size : 44 and 48 kDa (why is the actual band size different from the predicted?)
  • ab67232 at 2.5 µg/ml staining FBXL20 in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-FBXL20 antibody (ab67232) 使用論文

ab67232 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"