製品の概要

  • 製品名Anti-FBXL20 antibody
    FBXL20 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FBXL20
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 110-159 (RTFAQNCRNI EVLNLNGCTK TTDATCTSLS KFCSKLRHLD LASCTSITNM) of Human FBXL20 (NP_116264).

  • ポジティブ・コントロール
    • Human fetal brain lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性FBXL20 is a member of the F-box protein family, which are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. FBXL20 is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. FBXL20 has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. FBXL20 is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
  • 細胞内局在Cytoplasmic
  • 参照データベース
  • 別名
    • F box and leucine rich repeat protein 20 antibody
    • F box/LRR repeat protein 2 like antibody
    • F box/LRR repeat protein 20 antibody
    • Fbl2 antibody
    • Fbl20 antibody
    • MGC15482 antibody
    • SCR antibody
    • SCRAPPER antibody
    see all

Anti-FBXL20 antibody 画像

  • Anti-FBXL20 antibody (ab113803) at 1 µg/ml + Human fetal brain lysate at 10 µg

    Predicted band size : 48 kDa

Anti-FBXL20 antibody (ab113803) 使用論文

ab113803 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"