製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FBXL11
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Gorilla, Orangutan, Bat
  • 免疫原

    Synthetic peptide corresponding to a region between residue 825 and 875 (SSANLRHSPR VLVQHCPART PQRGDEEGLG GEEEEEEEEE EEDDSAEEGG A) of Human FBXL11 (NP_036440.1).

  • ポジティブ・コントロール
    • Human Anaplastic Thyroid Carcinoma, Breast Carcinoma, Lung Adenocarcinoma, Ovarian Carcinoma, Skin Basal Cell Carcinoma and Stomach Adenocarcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

ターゲット情報

  • 機能
    Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
  • 組織特異性
    Widely expressed, with highest levels in brain, testis and ovary, followed by lung.
  • 配列類似性
    Belongs to the JHDM1 histone demethylase family.
    Contains 1 CXXC-type zinc finger.
    Contains 1 F-box domain.
    Contains 1 JmjC domain.
    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 PHD-type zinc finger.
  • ドメイン
    The JmjC domain mediates demethylation activity and is required for satellite silencing.
    The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus > nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • [Histone-H3]-lysine-36 demethylase 1A antibody
    • CXXC-type zinc finger protein 8 antibody
    • CXXC8 antibody
    • F box / LRR repeat protein 11 antibody
    • F box and leucine rich repeat protein 11 antibody
    • F box protein FBL7 antibody
    • F-box and leucine-rich repeat protein 11 antibody
    • F-box protein FBL7 antibody
    • F-box protein Lilina antibody
    • F-box/LRR-repeat protein 11 antibody
    • FBL11 antibody
    • FBL7 antibody
    • FBXL11 antibody
    • JHDM1A antibody
    • JmjC domain-containing histone demethylation protein 1A antibody
    • Jumonji C domain containing histone demethylase 1A antibody
    • kdm2a antibody
    • KDM2A_HUMAN antibody
    • LILINA antibody
    • Lysine (K) specific demethylase 2A antibody
    • Lysine-specific demethylase 2A antibody
    see all

Anti-FBXL11 antibody 画像

  • ab99242, at 1/250 dilution, staining FBXL11 in formalin-fixed paraffin-embedded Human skin basal cell carcinoma by Immunohistochemistry using DAB staining.
  • ab99242, at 1/250 dilution, staining FBXL11 in formalin-fixed paraffin-embedded Human breast carcinoma by Immunohistochemistry using DAB staining.

プロトコール

Anti-FBXL11 antibody (ab99242) 使用論文

ab99242 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab99242.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録