製品の概要

  • 製品名Anti-FBP17 antibody
    FBP17 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to FBP17
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Zebrafish
  • 免疫原

    Synthetic peptide:

    KQLESSKRRFERDC

    , corresponding to amino acids 132 - 145 of Human FBP17.

  • ポジティブ・コントロール
    • Human Testis lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab23934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報Peptide ELISA: 1/32000.
    WB: Use at a concentration of 0.25 - 2.0 µg/ml. Predicted molecular weight: 70 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
    • 組織特異性Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
    • 関連疾患Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
    • 配列類似性Belongs to the FNBP1 family.
      Contains 1 FCH domain.
      Contains 1 REM (Hr1) repeat.
      Contains 1 SH3 domain.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
    • Information by UniProt
    • 参照データベース
    • 別名
      • FBP1 antibody
      • FBP17 antibody
      • Fnbp1 antibody
      • FNBP1_HUMAN antibody
      • Formin binding protein 1 antibody
      • Formin binding protein 17 antibody
      • Formin-binding protein 1 antibody
      • Formin-binding protein 17 antibody
      • hFBP17 antibody
      • KIAA0554 antibody
      • MGC126804 antibody
      see all

    Anti-FBP17 antibody 画像

    • Anti-FBP17 antibody (ab23934) at 0.25 µg/ml + Human Testis lysate (RIPA buffer, 35µg total protein per lane).

      Predicted band size : 70 kDa
      Observed band size : 70 kDa

    Anti-FBP17 antibody (ab23934) 使用論文

    ab23934 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab23934.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"