製品の概要

  • 製品名
    Anti-Fascin 2 antibody
  • 製品の詳細
    Goat polyclonal to Fascin 2
  • 特異性
    ab78599 is expected to recognize both reported isoforms (NP_001070650.1 and NP_036550.1) of Fascin 2.
  • アプリケーション
    適用あり: ICC/IF, WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Cow, Dog, Human
  • 免疫原

    Synthetic peptide:

    CHHRGSNQLDTNR

    , corresponding to internal sequence amino acids of Human Fascin 2 (NP_001070650.1 and NP_036550.1)

  • ポジティブ・コントロール
    • Mouch cochlea.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab78599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Preliminary experiments gave bands at approx 75kDa and 22kDa in Mouse Eye lysates after 0.05µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

ターゲット情報

  • 機能
    Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
  • 組織特異性
    Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.
  • 関連疾患
    Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.
  • 配列類似性
    Belongs to the fascin family.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Cell projection > stereocilium.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Fascin homolog 2, actin bundling protein, retinal Strongylocentrotus purpuratus antibody
    • Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein, retinal antibody
    • Fascin-2 antibody
    • FSCN2 antibody
    • FSCN2_HUMAN antibody
    • Retinal fascin antibody
    • RFSN antibody
    • RP30 antibody
    see all

参考文献

This product has been referenced in:
  • Sui X  et al. p53 controls colorectal cancer cell invasion by inhibiting the NF-?B-mediated activation of Fascin. Oncotarget 6:22869-79 (2015). Read more (PubMed: 26362504) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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