製品の概要
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製品名Anti-Fas Ligand antibody [MM0268- 1Z20]
Fas Ligand 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [MM0268- 1Z20] to Fas Ligand
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由来種Mouse
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アプリケーション適用あり: WBmore details
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種交差性交差種: Human
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免疫原
Recombinant Human Fas Ligand extracellular domain.
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特記事項
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized mouse).
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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バッファーPreservative: None
Constituents: PBS -
Concentration information loading... -
精製度Protein G purified
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特記事項（精製）The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
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一次抗体 備考This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized mouse).
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ポリ/モノモノクローナル
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クローン名MM0268- 1Z20
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アイソタイプIgG1
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab89292 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/1000. Predicted molecular weight: 31 kDa. |
ターゲット情報
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機能Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
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関連疾患Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
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配列類似性Belongs to the tumor necrosis factor family.
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翻訳後修飾N-glycosylated.
The soluble form derives from the membrane form by proteolytic processing. -
細胞内局在Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.
- Information by UniProt
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参照データベース
- Entrez Gene: 356 Human
- Omim: 134638 Human
- SwissProt: P48023 Human
- Unigene: 2007 Human
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別名
- ALPS1B antibody
- Apoptosis (APO 1) antigen ligand 1 antibody
- Apoptosis antigen ligand 1 antibody
see all
プロトコール
参考文献
ab89292 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"