Anti-Fas Ligand 抗体 [MM0268- 1Z20] (ab89292)

製品の概要

• 製品名
  Anti-Fas Ligand antibody [MM0268- 1Z20]
  Fas Ligand 一次抗体 製品一覧
• 製品の詳細
  Mouse monoclonal [MM0268- 1Z20] to Fas Ligand
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Recombinant Human Fas Ligand extracellular domain.

• 特記事項

  
  

  This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized mouse).

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• 精製度
  Protein G purified
• 特記事項（精製）
  The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
• 一次抗体 備考
  This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized mouse).
• ポリ/モノ
  モノクローナル
• クローン名
  MM0268- 1Z20
• アイソタイプ
  IgG1
• 研究分野
  • Cell Biology
  • Apoptosis
  • Extracellular Signals
  • Death Ligands

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Immunology
  • Immune System Diseases
  • Autoimmune

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能
  Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
• 関連疾患
  Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
• 配列類似性
  Belongs to the tumor necrosis factor family.
• 翻訳後修飾
  N-glycosylated.
  The soluble form derives from the membrane form by proteolytic processing.
• 細胞内局在
  Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.

• Target information above from: UniProt accession P48023 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 356 Human
  • Omim: 134638 Human
  • SwissProt: P48023 Human
  • Unigene: 2007 Human
• 別名
  • ALPS1B antibody
  • Apoptosis (APO 1) antigen ligand 1 antibody
  • Apoptosis antigen ligand 1 antibody

  • Apoptosis antigen ligand antibody
  • APT1LG1 antibody
  • APTL antibody
  • CD178 antibody
  • CD178 antigen antibody
  • CD95 ligand antibody
  • CD95-L antibody
  • CD95L antibody
  • CD95L protein antibody
  • Fas antigen ligand antibody
  • Fas L antibody
  • Fas ligand (TNF superfamily member 6) antibody
  • Fas ligand antibody
  • FASL antibody
  • Fasl Fas ligand (TNF superfamily member 6) antibody
  • FASLG antibody
  • Generalized lymphoproliferative disease antibody
  • Gld antibody
  • soluble form antibody
  • TNFL6_HUMAN antibody
  • TNFSF6 antibody
  • Tumor necrosis factor (ligand) superfamily member 6 antibody
  • Tumor necrosis factor ligand superfamily member 6 antibody

  see all

プロトコール

• Western blot protocols