Anti-Fas Ligand 抗体 [MFL3] (Phycoerythrin) (ab93566)

製品の概要

• 製品名Anti-Fas Ligand antibody [MFL3] (Phycoerythrin)
  Fas Ligand 一次抗体 製品一覧
• 製品の詳細
  Armenian Hamster monoclonal [MFL3] to Fas Ligand (Phycoerythrin)
• 標識Phycoerythrin. Ex: 488nm, Em: 575nm
• アプリケーション適用あり: Flow Cytmore details
• 種交差性
  交差種: Mouse
  
• 免疫原

  B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells.

• ポジティブ･コントロール
  • Mouse Fas Ligand transfected cells and activated T cells

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C.
• バッファーPreservative: 0.09% Sodium Azide
  Constituents: PBS, 150mM Sodium chloride, pH 7.2
• Concentration information loading...
• 精製度Protein G purified
• ポリ/モノモノクローナル
• クローン名MFL3
• アイソタイプIgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Extracellular Signals
  • Death Ligands

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Immunology
  • Immune System Diseases
  • Autoimmune

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

アプリケーション

ターゲット情報

• 機能Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
• 関連疾患Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
• 配列類似性Belongs to the tumor necrosis factor family.
• 翻訳後修飾N-glycosylated.
  The soluble form derives from the membrane form by proteolytic processing.
• 細胞内局在Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.

• Target information above from: UniProt accession P48023 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 14103 Mouse
  • SwissProt: P41047 Mouse
  • Unigene: 3355 Mouse
• 別名
  • ALPS1B antibody
  • Apoptosis (APO 1) antigen ligand 1 antibody
  • Apoptosis antigen ligand 1 antibody

  • Apoptosis antigen ligand antibody
  • APT1LG1 antibody
  • APTL antibody
  • CD178 antibody
  • CD178 antigen antibody
  • CD95 ligand antibody
  • CD95-L antibody
  • CD95L antibody
  • CD95L protein antibody
  • Fas antigen ligand antibody
  • Fas L antibody
  • Fas ligand (TNF superfamily member 6) antibody
  • Fas ligand antibody
  • FASL antibody
  • Fasl Fas ligand (TNF superfamily member 6) antibody
  • FASLG antibody
  • Generalized lymphoproliferative disease antibody
  • Gld antibody
  • soluble form antibody
  • TNFL6_HUMAN antibody
  • TNFSF6 antibody
  • Tumor necrosis factor (ligand) superfamily member 6 antibody
  • Tumor necrosis factor ligand superfamily member 6 antibody

  see all