製品の概要

  • 製品名Anti-Fas antibody [UT-1]
    Fas 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [UT-1] to Fas
  • アプリケーション適用あり: Functional Studies, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    T cell lymphoma cells HUT-78.

  • 特記事項The antibody is provided as a sterile solution.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab91545-Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
  • 組織特異性Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
  • 関連疾患Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 配列類似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • ドメインContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALPS 1A antibody
    • ALPS1A antibody
    • APO 1 antibody
    • Apo 1 antigen antibody
    • APO 1 cell surface antigen antibody
    • Apo-1 antigen antibody
    • APO1 antibody
    • Apo1 antigen antibody
    • APO1 cell surface antigen antibody
    • Apoptosis antigen 1 antibody
    • Apoptosis mediating surface antigen FAS antibody
    • Apoptosis-mediating surface antigen FAS antibody
    • APT 1 antibody
    • APT1 antibody
    • CD 95 antibody
    • CD 95 antigen antibody
    • CD95 antibody
    • CD95 antigen antibody
    • Delta Fas antibody
    • Delta Fas/APO 1/CD95 antibody
    • Delta Fas/APO1/CD95 antibody
    • Fas (TNF receptor superfamily, member 6) antibody
    • FAS 1 antibody
    • FAS 827dupA antibody
    • Fas AMA antibody
    • Fas antibody
    • FAS Antigen antibody
    • Fas cell surface death receptor antibody
    • FAS1 antibody
    • FASLG receptor antibody
    • FASTM antibody
    • sFAS antibody
    • Surface antigen APO1 antibody
    • TNF receptor superfamily, member 6 antibody
    • TNFRSF 6 antibody
    • TNFRSF6 antibody
    • TNR6_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 6 antibody
    see all

Anti-Fas antibody [UT-1] 画像

  • Flow Cytometry analysis of jurkat human peripheral blood T cell leukemia cell line labeling Fas with ab11881. Suspension of jurkat cell line was incubated with soluble (or without as control) anti-Fas antibodies ab11881. Induction of apoptosis was measured by Apoptosis Assay Kit - FITC. Red: untreated control cells, Black: standard apoptosis-inducing anti-Fas antibody,
    Green: Anti-Fas antibody [UT-1] (ab11881).

     

  • Flow Cytometry analysis of TF-1 human bone marrow erythroleukemia cell line labeling Fas with ab11881. Suspension of TF-1 cell line was incubated with soluble (or without as control) anti-Fas antibodies (ab11881). Induction of apoptosis was measured by Apoptosis Assay Kit - FITC. Red: untreated control cells, Black: standard apoptosis-inducing anti-Fas antibody,
    Green: Anti-Fas antibody [UT-1] (ab11881).

  • Flow Cytometry analysis of MOLT-4 human acute lymphoblastic T cell leukemia cell line labeling Fas with ab11881. Suspension of MOLT-4 cell line was incubated with soluble (or without as control) anti-Fas antibodies (ab11881). Induction of apoptosis was measured by Apoptosis Assay Kit - FITC. Red: untreated control cells, Black: standard apoptosis-inducing anti-Fas antibody,
    Green: Anti-Fas antibody [UT-1] (ab11881).

Anti-Fas antibody [UT-1] (ab11881) 使用論文

ab11881 has not yet been referenced specifically in any publications.

Product Wall

ab11881, ab34359 antibodies can be used in Biological studies which include apoptosis. Please be advised that the experimental conditions has to be optimized by the end user. We also have Apoptosis inducer KITs available in catalogue with ab102480; ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"