製品の概要

  • 製品名Anti-Fas antibody [LT95]
    Fas 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [LT95] to Fas
  • 特異性Human Fas (CD95/APO-1).
  • アプリケーション適用あり: IHC-P, Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Tissue, cells or virus corresponding to Human Fas.

  • ポジティブ・コントロール
    • Reacts strongly with IM9 and HUT-78 cell lines. Reacts moderately with Raji, Ramos, U266, Jurkat, BJAB and ML-1 cell lines. Reacts weakly with KG1a, U937, KM3 and TF-1 cell lines. Does not react with K562 and THP-1 cell lines.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab1088 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ターゲット情報

  • 機能Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
  • 組織特異性Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
  • 関連疾患Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 配列類似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • ドメインContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALPS 1A antibody
    • ALPS1A antibody
    • APO 1 antibody
    • Apo 1 antigen antibody
    • APO 1 cell surface antigen antibody
    • Apo-1 antigen antibody
    • APO1 antibody
    • Apo1 antigen antibody
    • APO1 cell surface antigen antibody
    • Apoptosis antigen 1 antibody
    • Apoptosis mediating surface antigen FAS antibody
    • Apoptosis-mediating surface antigen FAS antibody
    • APT 1 antibody
    • APT1 antibody
    • CD 95 antibody
    • CD 95 antigen antibody
    • CD95 antibody
    • CD95 antigen antibody
    • Delta Fas antibody
    • Delta Fas/APO 1/CD95 antibody
    • Delta Fas/APO1/CD95 antibody
    • Fas (TNF receptor superfamily, member 6) antibody
    • FAS 1 antibody
    • FAS 827dupA antibody
    • Fas AMA antibody
    • Fas antibody
    • FAS Antigen antibody
    • Fas cell surface death receptor antibody
    • FAS1 antibody
    • FASLG receptor antibody
    • FASTM antibody
    • sFAS antibody
    • Surface antigen APO1 antibody
    • TNF receptor superfamily, member 6 antibody
    • TNFRSF 6 antibody
    • TNFRSF6 antibody
    • TNR6_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 6 antibody
    see all

Anti-Fas antibody [LT95] 画像

  • Flow cytometry analysis of Fas expression on the surface of various hematopoietic (A- Jurkat, B- Ramos, C- CEM and D- MOLT-4) cell lines with purified ab1088. Goat anti-mouse IgG was used as the secondart antibody.

    Histograms:

    Red – Isotype mouse IgG1 control staining

    Black – standard anti-Fas monoclonal antibody

    Green – Fas (LT95) staining with ab1088

Anti-Fas antibody [LT95] (ab1088) 使用論文

ab1088 has not yet been referenced specifically in any publications.

Product Wall

ab1088 does not induce Fas mediated apoptosis in susceptible cells. For the other four antibodies you specify, ab1121, ab1122, ab8283, and ab10040, I'm afraid that none of them have been tested to see whether they induce apoptosis to human Fas-expressi...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"