製品の概要

  • 製品名Anti-Fas antibody
    Fas 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Fas
  • アプリケーション適用あり: WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Macaque Monkey
  • 免疫原

    Synthetic peptide corresponding to Human Fas aa 197-210 (internal sequence). Synthetic peptide:

    KTCRKHRKENQGSH

    , corresponding to internal sequence amino acids 197-210 of Human Fas
    Sequence:

    KTCRKHRKENQGSH

  • ポジティブ・コントロール
    • Human small intestine tissue, Human tonsil tissue, MOLT4 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab110021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 38 kDa.
IHC-P Use a concentration of 3.75 µg/ml.
ELISA 1/32000.

ターゲット情報

  • 機能Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
  • 組織特異性Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
  • 関連疾患Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 配列類似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • ドメインContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALPS 1A antibody
    • ALPS1A antibody
    • APO 1 antibody
    • Apo 1 antigen antibody
    • APO 1 cell surface antigen antibody
    • Apo-1 antigen antibody
    • APO1 antibody
    • Apo1 antigen antibody
    • APO1 cell surface antigen antibody
    • Apoptosis antigen 1 antibody
    • Apoptosis mediating surface antigen FAS antibody
    • Apoptosis-mediating surface antigen FAS antibody
    • APT 1 antibody
    • APT1 antibody
    • CD 95 antibody
    • CD 95 antigen antibody
    • CD95 antibody
    • CD95 antigen antibody
    • Delta Fas antibody
    • Delta Fas/APO 1/CD95 antibody
    • Delta Fas/APO1/CD95 antibody
    • Fas (TNF receptor superfamily, member 6) antibody
    • FAS 1 antibody
    • FAS 827dupA antibody
    • Fas AMA antibody
    • Fas antibody
    • FAS Antigen antibody
    • Fas cell surface death receptor antibody
    • FAS1 antibody
    • FASLG receptor antibody
    • FASTM antibody
    • sFAS antibody
    • Surface antigen APO1 antibody
    • TNF receptor superfamily, member 6 antibody
    • TNFRSF 6 antibody
    • TNFRSF6 antibody
    • TNR6_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 6 antibody
    see all

Anti-Fas antibody 画像

  • ab110021, staining CD95 in Human small intestine tissue by immunohistochemistry.
  • ab110021, staining CD95 in Human tonsil tissue by immunohistochemistry.
  • Anti-Fas antibody (ab110021) at 0.1 µg/ml + MOLT4 cell lysate (in RIPA buffer) at 35 µg

    Predicted band size : 38 kDa
    Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Fas antibody (ab110021) 使用論文

ab110021 has not yet been referenced specifically in any publications.

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