製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to FANCL
  • 特異性
    ab105020 is expected to recognize both isoforms (NP_001108108.1; NP_060532.2).
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-QNLKDVLEIDFP

    , corresponding to internal sequence amino acids 282-293 of Human FANCL (NP_060532.2).

  • ポジティブ・コントロール
    • Human Bone Marrow lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab105020 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab105020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 43 kDa).

ターゲット情報

  • 機能
    Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 関連疾患
    Fanconi anemia complementation group L
  • 配列類似性
    Contains 1 RING-type zinc finger.
  • ドメイン
    The UBC-RWD region (URD) region mediates interaction with FANCI and FANCD2.
  • 翻訳後修飾
    The RING-type zinc finger domain is monoubiquitinated in the presence of UBE2T and UBE2W.
  • 細胞内局在
    Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • E3 ubiquitin-protein ligase FANCL antibody
    • FAAP43 antibody
    • Fancl antibody
    • FANCL_HUMAN antibody
    • Fanconi anemia complementation group L antibody
    • Fanconi anemia group L protein antibody
    • Fanconi anemia-associated polypeptide of 43 kDa antibody
    • FLJ10335 antibody
    • PHD finger protein 9 antibody
    • PHF9 antibody
    • POG antibody
    • Ubiquitin ligase protein FANCL antibody
    see all

Anti-FANCL antibody 画像

  • Anti-FANCL antibody (ab105020) at 1 µg/ml + Human Bone Marrow lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 43 kDa

プロトコール

Anti-FANCL antibody (ab105020) 使用論文

ab105020 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab105020.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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