The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 69 kDa.
Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
機能DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
組織特異性Highly expressed in testis and thymus. Found in lymphoblasts.
関連疾患Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
配列類似性Contains 4 TPR repeats.
細胞内局在Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human spleen tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
ab115230 at 3 ug/ml, staining FANCG in Formalin-fixed, Paraffin-embedded Human uterus tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
Anti-FANCG antibody (ab115230) 使用論文
has not yet been referenced specifically in any publications.