製品の概要

  • 製品名Anti-FANCB antibody
    FANCB 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to FANCB
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human), (NP_001018123).

  • ポジティブ・コントロール
    • FANCB transfected 293T cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 98 kDa.

ターゲット情報

  • 機能DNA repair protein required for FANCD2 ubiquitination.
  • 関連疾患Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB) [MIM:300514]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in FANCB are the cause of X-linked VACTERL-H (XVACTERL-H) [MIM:314390]; also known as X-linked VACTERL association with hydrocephalus syndrome. VACTERL is an acronym for vertebral anomalies, anal atresia, cardiac malformations, tracheoesophageal fistula, renal anomalies (urethral atresia with hydronephrosis), and limb anomalies (hexadactyly, humeral hypoplasia, radial aplasia, and proximally placed thumb). Some cases of VACTERL-H are associated with increased chromosome breakage and rearrangement.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FA2 antibody
    • FAAP90 antibody
    • FAAP95 antibody
    • FAB antibody
    • FACB antibody
    • Fancb antibody
    • FANCB_HUMAN antibody
    • Fanconi anemia associated polypeptide of 95 kDa antibody
    • Fanconi anemia group B protein antibody
    • Fanconi anemia, complementation group B antibody
    • Fanconi anemia-associated polypeptide of 95 kDa antibody
    • Protein FACB antibody
    see all

Anti-FANCB antibody 画像

  • All lanes : Anti-FANCB antibody (ab72810) at 1/500 dilution

    Lane 1 : FANCB transfected 293T cell lysate
    Lane 2 : Untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 98 kDa
    Observed band size : 105 kDa (why is the actual band size different from the predicted?)

Anti-FANCB antibody (ab72810) 使用論文

ab72810 has not yet been referenced specifically in any publications.

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