製品の概要

  • 製品名
    Anti-FAM126A antibody
  • 製品の詳細
    Rabbit polyclonal to FAM126A
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 178 and 416 of Human FAM126A (NP_115970).

  • ポジティブ・コントロール
    • 293T, A431, H1299 ,HeLa, HepG2, MOLT4 and Raji cell lysates

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab98144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.

ターゲット情報

  • 機能
    Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway.
  • 組織特異性
    Widely expressed. Highest levels in heart, brain, placenta, spleen and testis.
  • 関連疾患
    Leukodystrophy, hypomyelinating, 5
  • 配列類似性
    Belongs to the FAM126 family.
  • 細胞内局在
    Cytoplasm, cytosol. Cell membrane. Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Down regulated by Ctnnb1 a antibody
    • Down regulated by CTNNB1 protein A antibody
    • Down-regulated by CTNNB1 protein A antibody
    • DRCTNNB1A antibody
    • FAM126A antibody
    • Family with sequence similarity 126 member A antibody
    • HCC antibody
    • HLD5 antibody
    • HYCC1 antibody
    • HYCCI_HUMAN antibody
    • Hyccin antibody
    • Protein FAM126A antibody
    see all

画像

  • Anti-FAM126A antibody (ab98144) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 58 kDa

プロトコール

参考文献

ab98144 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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