製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to FAM120A
  • 特異性
    ab106454 will not cross-react with FAM120B / PGCC1.
  • アプリケーション
    適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    An 18 amino acid synthetic peptide from near the center of Human FAM120A (NP_055427).

  • ポジティブ・コントロール
    • SK-N-SH cell lysate; Rat brain tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 122 kDa.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.
  • 組織特異性
    Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level).
  • 配列類似性
    Belongs to the constitutive coactivator of PPAR-gamma family.
  • 翻訳後修飾
    Arg-982 is dimethylated, probably to asymmetric dimethylarginine.
    Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.
  • 細胞内局在
    Cytoplasm. Cell membrane. Translocates to plasma membrane upon ultraviolet exposure.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C9orf10 antibody
    • Chromosome 9 open reading frame 10 antibody
    • Constitutive coactivator of PPAR gamma like protein 1 antibody
    • Constitutive coactivator of PPAR-gamma-like protein 1 antibody
    • DNA polymerase transactivated protein 5 antibody
    • DNA polymerase transactivated protein 1 antibody
    • DNAPTP1 antibody
    • DNAPTP5 antibody
    • F120A_HUMAN antibody
    • FAM120A antibody
    • Family with sequence similarity 120A antibody
    • Hypothetical protein LOC23196 antibody
    • KIAA0183 antibody
    • LOC23196 antibody
    • MGC111527 antibody
    • MGC133257 antibody
    • OSSA antibody
    • Oxidative stress-associated Src activator antibody
    • Protein FAM120A antibody
    see all

画像

  • Lane 1 : Anti-FAM120A antibody (ab106454) at 0.5 µg/ml
    Lane 2 : Anti-FAM120A antibody (ab106454) at 1 µg/ml

    Lane 1 : SK-N-SH cell lysate
    Lane 2 : SK-N-SH cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 122 kDa
  • ab106454, at 2.5µg/ml, staining FAM120A in Rat brain tissue by Immunohistochemistry.
  • Immunofluorescence of FAM120A in Rat Brain cells using ab106454 at 20 ug/ml.

参考文献

ab106454 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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