製品の概要

  • 製品名Anti-FAIM3 antibody
    FAIM3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FAIM3
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 13 amino acids near the C terminal of Human FAIM3.

  • ポジティブ・コントロール
    • Human kidney tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab115211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 組織特異性Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells.
  • 配列類似性Contains 1 Ig-like (immunoglobulin-like) domain.
  • ドメインThe Ig-like domain is required for the anti-apoptotic ability.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Faim3 antibody
    • FAIM3_HUMAN antibody
    • Fas apoptotic inhibitory molecule 3 antibody
    • Fc mu receptor antibody
    • FCMR antibody
    • IgM Fc receptor antibody
    • Immunoglobulin mu Fc receptor antibody
    • Regulator of Fas induced apoptosis antibody
    • Regulator of Fas-induced apoptosis Toso antibody
    • TOSO antibody
    see all

Anti-FAIM3 antibody 画像

  • ab115211, at 5 ug/ml, staining FAIM3 in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-FAIM3 antibody (ab115211) 使用論文

ab115211 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"