製品の概要

  • 製品名Anti-Factor XI antibody (Biotin)
    Factor XI 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Factor XI (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: WB, ELISA, RIAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Human Factor XI purified from Human plasma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab105847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 70 kDa.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

ターゲット情報

  • 機能Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • 組織特異性Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
  • 関連疾患Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
  • 配列類似性Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
    Contains 4 apple domains.
    Contains 1 peptidase S1 domain.
  • 翻訳後修飾Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Coagulation factor XI antibody
    • Coagulation factor XIa light chain antibody
    • F11 antibody
    • FA11_HUMAN antibody
    • FXI antibody
    • MGC141891 antibody
    • Plasma thromboplastin antecedent antibody
    • PTA antibody
    see all

Anti-Factor XI antibody (Biotin) (ab105847) 使用論文

ab105847 has not yet been referenced specifically in any publications.

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