The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
Use at an assay dependent dilution.
Use at an assay dependent dilution. This antibody inhibits PT, prothrombinase and partially APTT, but not amidase activity.
機能Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
組織特異性Plasma; synthesized in the liver.
関連疾患Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
配列類似性Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla (gamma-carboxy-glutamate) domain. Contains 1 peptidase S1 domain.
翻訳後修飾The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
製品の状態Cleaved into the following 3 chains:
1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
Activated factor Xa heavy chain antibody
Coagulation factor X antibody
factor Xa antibody
Stuart factor antibody
Stuart Prower factor antibody
Stuart-Prower factor antibody
Anti-Factor X antibody (ab61361) 使用論文
This product has been referenced in:
Böhm A et al. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. Cardiovasc Res99:505-13 (2013).
Read more (PubMed: 23658376) »