製品の概要

  • 製品名Anti-Factor X antibody
    Factor X 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to Factor X
  • 特異性This antibody recognizes the heavy chains of human factors Xa and X; it does not bind bovine factor X or BEGRck-Xa.
  • アプリケーション適用あり: WB, ELISA, Purificationmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length native purified Human Factor X

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 50% (v/v)Glycerol/water
  • Concentration information loading...
  • 精製度Ion Exchange Chromatography
  • 特記事項(精製)Salt fractionation followed by gel filtration and ion exchange chromatography.
  • ポリ/モノモノクローナル
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab61361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
ELISA Use at an assay dependent dilution.
Purification Use at an assay dependent dilution. This antibody inhibits PT, prothrombinase and partially APTT, but not amidase activity.

ターゲット情報

  • 機能Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • 組織特異性Plasma; synthesized in the liver.
  • 関連疾患Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
  • 配列類似性Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻訳後修飾The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    N- and O-glycosylated.
    The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 製品の状態Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
  • 別名
    • Activated factor Xa heavy chain antibody
    • Coagulation factor X antibody
    • F10 antibody
    • FA10_HUMAN antibody
    • factor Xa antibody
    • FX antibody
    • FXA antibody
    • Prothrombinase antibody
    • Stuart factor antibody
    • Stuart Prower factor antibody
    • Stuart-Prower factor antibody
    see all

Anti-Factor X antibody (ab61361) 使用論文

This product has been referenced in:
  • Böhm A  et al. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. Cardiovasc Res 99:505-13 (2013). WB, IHC-P ; Human . Read more (PubMed: 23658376) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"