製品の概要

  • 製品名
  • 製品の詳細
    Sheep polyclonal to Factor X
  • アプリケーション
    適用あり: ELISA, IHC-P, Immunodiffusion, Immunoelectrophoresismore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Macaque monkey
  • 免疫原

    Full length native Human Factor X, purified from human plasma, activated and the active site blocked.

  • ポジティブ・コントロール
    • Human small intestine vessels, Human liver vessels.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    pH: 7.40
    Constituents: 0.238% HEPES, 0.8766% Sodium chloride, 50% Glycerol
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab110138 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 5 µg/ml.
Immunodiffusion Use at an assay dependent dilution.
Immunoelectrophoresis Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • 組織特異性
    Plasma; synthesized in the liver.
  • 関連疾患
    Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.
  • 配列類似性
    Belongs to the peptidase S1 family.
    Contains 2 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 1 peptidase S1 domain.
  • 翻訳後修飾
    The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
    N- and O-glycosylated.
    The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • 細胞内局在
    Secreted.
  • Information by UniProt
  • 参照データベース
  • 製品の状態
    Cleaved into the following 3 chains: 1. Factor X light chain 2. Factor X heavy chain 3. Activated factor Xa heavy chain
  • 別名
    • Activated factor Xa heavy chain antibody
    • Coagulation factor X antibody
    • F10 antibody
    • FA10_HUMAN antibody
    • factor Xa antibody
    • FX antibody
    • FXA antibody
    • Prothrombinase antibody
    • Stuart factor antibody
    • Stuart Prower factor antibody
    • Stuart-Prower factor antibody
    see all

画像

  • ab110138, at 5 µg/ml, staining F10 in vessels in Human small intestine by immunohistochemistry.
  • ab110138, at 5 µg/ml, staining a vessel in Human liver by immunohistochemistry.

プロトコール

参考文献

ab110138 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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