Anti-Factor VIII 抗体 [27.4] (ab41188)


  • 製品名
    Anti-Factor VIII antibody [27.4]
    Factor VIII 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [27.4] to Factor VIII
  • 特異性
    ab41188 does not cross react with the von Willebrand factor.
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    N-terminal region of the 83kD light chain of purified human Factor VIII.

  • エピトープ
    ab41188 recognises an epitope in the N-terminal region of the 83kD light chain of Factor VIII.
  • 特記事項
    Stable for at least 1 year at -20°C to -70°C.


  • 製品の状態
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
  • クローン名
  • アイソタイプ
  • 研究分野


Our Abpromise guarantee covers the use of ab41188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報
    ELISA: 1/16,000.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 267 kDa.

    Dilute in PBS or medium which is identical to that used in the assay system.

    Can inhibit Factor VIII activity in coagulation assays.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
    • 関連疾患
      Defects in F8 are the cause of hemophilia A (HEMA) [MIM:306700]. A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery. Note=Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non-functional; i.e., the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein.
    • 配列類似性
      Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 2 F5/8 type C domains.
      Contains 6 plastocyanin-like domains.
    • ドメイン
      Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity.
    • 翻訳後修飾
      Sulfation on Tyr-1699 is essential for binding vWF.
    • 細胞内局在
      Secreted > extracellular space.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AHF antibody
      • Antihemophilic factor antibody
      • Coagulation factor VIII antibody
      • coagulation factor VIII, procoagulant component antibody
      • coagulation factor VIIIc antibody
      • DXS1253E antibody
      • F8 antibody
      • F8b antibody
      • F8c antibody
      • FA8_HUMAN antibody
      • factor VIII F8B antibody
      • Factor VIIIa light chain antibody
      • FactorVIII antibody
      • FVIII antibody
      • Hema antibody
      • Hemophilia A antibody
      • Hemophilia, classic antibody
      • OTTHUMP00000061446 antibody
      • OTTHUMP00000196174 antibody
      • Procoagulant component antibody
      see all


    Anti-Factor VIII antibody [27.4] (ab41188) 使用論文

    ab41188 has not yet been referenced specifically in any publications.

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    I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement for one vial of ab41188 with the order number 973153. To check the status of the orde...

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