製品の概要

  • 製品名Anti-Factor Va antibody
  • 製品の詳細
    Sheep polyclonal to Factor Va
  • 特異性This antibody recognizes Human Factor Va.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Native, purified human Factor Va

  • 特記事項Concentration 5-10mg/ml (lot specific).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 50% Glycerol/ Water
  • Concentration information loading...
  • 精製度Ion Exchange Chromatography
  • 特記事項(精製)Salt fractionation followed by ion exchange chromatography on DEAE sepharose.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab81460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 168 kDa.

ターゲット情報

  • 関連性Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by alpha-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (MW 94kDa) and a COOH-terminal derived light chain (MW 74kDa) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain.
  • 細胞内局在Cell Membrane and Plasma membrane
  • 参照データベース
  • 別名
    • Activated protein c cofactor antibody
    • Coagulation factor V (proaccelerin, labile factor) antibody
    • Coagulation factor V antibody
    • F5 antibody
    • Factor V Leiden antibody
    • FVL antibody
    • PCCF antibody
    see all

Anti-Factor Va antibody (ab81460) 使用論文

ab81460 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"