Anti-Factor V Light Chain 抗体 [CBC-MOR101] (ab1009)

製品の概要

  • 製品名Anti-Factor V Light Chain antibody [CBC-MOR101]
    Factor V Light Chain 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [CBC-MOR101] to Factor V Light Chain
  • 特異性This antibody reacts with the light chain (mw ~74,000) of human Factor V.
  • アプリケーション適用あり: ELISA, IHC-P, IHC-Fr, Neutralisingmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Purified human Factor V.

  • エピトープThis antibody recognizes an epitope (exact sequence unknown) in the F1F2 polypeptide of human Factor V and activated Factor V (Factor Va).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPBS, pH7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • クローン名CBC-MOR101
  • アイソタイプIgG1
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab1009 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
IHC-P
IHC-Fr
Neutralising
  • 追加情報This antibody neutralizes Factor V activity. KD = 0.3 x 10-10mol/L.
    This antibody can also be used for autoradiography.
  • ターゲット情報

    • 関連性Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin. Factor Va is composed of a heavy chain and a light chain, noncovalently bound. The interaction between the two chains is calcium-dependent. Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus). Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity. Defects in F5 are the cause of Owren parahemophilia which is an hemorrhagic diastesis. Defects in F5 are the cause of resistance to activated protein C (APCR). APCR is a form of thrombophilia. The APCR mutation is found in about 5% of the population which suggest that a slight thrombotic tendency may confer some advantage in fetal implantation.
    • 細胞内局在Secreted
    • 参照データベース
    • 別名
      • Activated protein C cofactor antibody
      • Coagulation factor V antibody
      • Coagulation factor V heavy chain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      see all

    Anti-Factor V Light Chain antibody [CBC-MOR101] (ab1009) 使用論文

    This product has been referenced in:

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry. These antibodies are two different clones. Ab1009 - Mouse monoclonal [CBC-MOR101] to Factor V Light Chain - recognizes an epitope (exact sequence unknown) in the F1F2 polypeptide of human Factor V and actiVated Factor V (Fac...

    Read More

    Thank you for your enquiry. For ab21037, the antibody was tested against purified Human Factor V and against human plasma in ELISA and Western blot. The characterization of ab20951, MAb to Factor V (Clone 701), was described in the following publish...

    Read More

    Anti-Factor V staining is seen in the cytoplasm of platelets and megakaryo-cytes.

    Human bone marrow smears can be used. Marrows are smeared, air-dried, fixed immediately in methanol:acetone (1:9) and stored frozen at -20 C until used.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"