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RabMAb

Anti-Factor V 抗体 [EPR5191] (ab108614)

製品の概要

  • 製品名
    Anti-Factor V antibody [EPR5191]
    Factor V 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR5191] to Factor V
  • アプリケーション
    適用あり: Flow Cyt, WBmore details
    適用なし: ICC,IHC-P or IP
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues in the light chain of Human Factor V

  • ポジティブ・コントロール
    • Human plasma and platelet lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファー
    PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 精製度
    Tissue culture supernatant
  • ポリ/モノ
    モノクローナル
  • クローン名
    EPR5191
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab108614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use at an assay dependent concentration. PubMed: 27492853
WB 1/1000 - 1/10000. Predicted molecular weight: 252 kDa.
  • 追加情報
    Is unsuitable for ICC,IHC-P or IP.
  • ターゲット情報

    • 機能
      Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
    • 組織特異性
      Plasma.
    • 関連疾患
      Factor V deficiency
      Thrombophilia due to activated protein C resistance
      Budd-Chiari syndrome
      Ischemic stroke
      Pregnancy loss, recurrent, 1
    • 配列類似性
      Belongs to the multicopper oxidase family.
      Contains 3 F5/8 type A domains.
      Contains 2 F5/8 type C domains.
      Contains 6 plastocyanin-like domains.
    • ドメイン
      Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.
    • 翻訳後修飾
      Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
      Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
      Activated protein C inactivates factor V and factor Va by proteolytic degradation.
      Phosphorylation sites are present in the extracellular medium.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Activated protein C cofactor antibody
      • APC cofactor antibody
      • coagulation factor V (proaccelerin, labile factor) antibody
      • Coagulation factor V antibody
      • coagulation factor V jinjiang A2 domain antibody
      • Coagulation factor V light chain antibody
      • F5 antibody
      • FA5_HUMAN antibody
      • Factor V Leiden antibody
      • FactorV antibody
      • FVL antibody
      • Labile factor antibody
      • PCCF antibody
      • Proaccelerin antibody
      • proaccelerin, labile factor antibody
      • Protein C cofactor antibody
      • RPRGL1 antibody
      • THPH2 antibody
      see all

    画像

    • All lanes : Anti-Factor V antibody [EPR5191] (ab108614) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : Human platelet lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 252 kDa

    参考文献

    This product has been referenced in:
    • Kaliberov SA  et al. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther N/A:N/A (2016). Flow Cyt ; Human . Read more (PubMed: 27492853) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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