製品の概要

  • 製品名Anti-Factor IX antibody [8.H.1]
    Factor IX 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [8.H.1] to Factor IX
  • 特異性This anditboy recognizes Factor IX, Factor IXa and heavy chain of Factor IX and IXa.
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Factor IX protein (Human).

  • ポジティブ・コントロール
    • High salt precipitation and ion-exchange chromatography.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab31680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
  • 追加情報ELISA: Suggested dilution: Coating: 5-10 µg/ml; Secondary: 100-1000 µg/ml.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
    • 組織特異性Synthesized primarily in the liver and secreted in plasma.
    • 関連疾患Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
      Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
      Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis.
    • 配列類似性Belongs to the peptidase S1 family.
      Contains 2 EGF-like domains.
      Contains 1 Gla (gamma-carboxy-glutamate) domain.
      Contains 1 peptidase S1 domain.
    • ドメインCalcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.
    • 翻訳後修飾Activated by factor XIa, which excises the activation peptide.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Christmas Disease antibody
      • Christmas factor antibody
      • Coagulant factor IX antibody
      • Coagulation factor 9 antibody
      • Coagulation factor IX antibody
      • Coagulation factor IXa heavy chain antibody
      • F9 antibody
      • FA9_HUMAN antibody
      • Factor 9 antibody
      • Factor IX Deficiency antibody
      • FactorIX antibody
      • FIX antibody
      • Haemophilia B antibody
      • HEMB antibody
      • MGC129641 antibody
      • MGC129642 antibody
      • P19 antibody
      • Plasma Thromboplastic Component antibody
      • Plasma thromboplastin component antibody
      • PTC antibody
      see all

    Anti-Factor IX antibody [8.H.1] (ab31680) 使用論文

    ab31680 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"