製品の概要

  • 製品名Anti-Factor I antibody [3D6]
    Factor I 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3D6] to Factor I
  • 特異性ab52244 is specific for the a-chain of human factor I
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Factor I isolated from human plasma

  • ポジティブ・コントロール
    • Normal human plasma

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 0.5M Sodium chloride, 10mM PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノモノクローナル
  • クローン名3D6
  • ミエローマx63-Ag8.653
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab52244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Use under non reducing condition. Predicted molecular weight: 65 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
  • 組織特異性Plasma.
  • 関連疾患Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3) [MIM:612923]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
    Defects in CFI are the cause of complement factor I deficiency (CFI deficiency) [MIM:610984]. CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections.
  • 配列類似性Belongs to the peptidase S1 family.
    Contains 1 Kazal-like domain.
    Contains 2 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • 細胞内局在Secreted > extracellular space.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AHUS3 antibody
    • ARMD13 antibody
    • C3b INA antibody
    • C3b inactivator antibody
    • C3B/C4B inactivator antibody
    • C3BINA antibody
    • CFAI_HUMAN antibody
    • Cfi antibody
    • Complement component I antibody
    • Complement control protein factor I antibody
    • Complement factor I antibody
    • Complement factor I heavy chain antibody
    • Complement factor I light chain antibody
    • F1 antibody
    • factor I antibody
    • FactorI antibody
    • FI antibody
    • I factor antibody
    • IF antibody
    • KAF antibody
    • Konglutinogen activating factor antibody
    • Light chain of factor I antibody
    • OTTHUMP00000219728 antibody
    • OTTHUMP00000221928 antibody
    see all

Anti-Factor I antibody [3D6] (ab52244) 使用論文

ab52244 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"