製品の概要

  • 製品名Anti-FA2H antibody
    FA2H 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to FA2H
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within C-terminal amino acids 257-306 (HGQHHKAPFD GSRLVFPPVP ASLVIAFFYV FLRLILPETV GGIIFAGGLL) of Mouse FA2H (NP_835187).

  • ポジティブ・コントロール
    • Mouse liver lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.
  • 組織特異性Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney.
  • 関連疾患Defects in FA2H are the cause of leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia (DLDSP) [MIM:612443]. The disorder consists of a progressive neurologic disease manifested by spasticity, disordered tonicity of muscle, and white matter degeneration.
    Defects in FA2H are a cause of spastic paraplegia autosomal recessive type 35 (SPG35) [MIM:612319]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
  • 配列類似性Belongs to the sterol desaturase family. SCS7 subfamily.
    Contains 1 cytochrome b5 heme-binding domain.
  • ドメインThe histidine box domains may contain the active site and/or be involved in metal ion binding.
  • 細胞内局在Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FA2H antibody
    • FA2H_HUMAN antibody
    • FAAH antibody
    • FAH1 antibody
    • Fatty acid 2 hydroxylase antibody
    • Fatty acid 2-hydroxylase antibody
    • Fatty acid alpha hydroxylase antibody
    • Fatty acid alpha-hydroxylase antibody
    • Fatty acid hydroxylase domain containing 1 antibody
    • FAXDC1 antibody
    • FLJ25287 antibody
    • SCS7 antibody
    • Spastic paraplegia 35 (autosomal recessive) antibody
    • SPG35 antibody
    see all

Anti-FA2H antibody 画像

  • Anti-FA2H antibody (ab111554) at 1 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 43 kDa

Anti-FA2H antibody (ab111554) 使用論文

ab111554 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"