Anti-Ezrin / Radixin / Moesin 抗体 (ab118572)

製品の概要

  • 製品名Anti-Ezrin / Radixin / Moesin antibody
  • 製品の詳細
    Rabbit polyclonal to Ezrin / Radixin / Moesin
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region near the C terminus of Human Ezrin/ Radixin/ Moesin.

  • ポジティブ・コントロール
    • Human Breast tissue and Mouse NIH-3T3 cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.
ELISA 1/20000.
IHC-P Use a concentration of 10 µg/ml.

ターゲット情報

  • 関連性Ezrin is a cytoplasmic peripheral membrane protein and functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
  • 細胞内局在Cell Membrane, Cytoskeleton and Cytoplasmic
  • 参照データベース
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Anti-Ezrin / Radixin / Moesin antibody 画像

  • ab118572, at 10 µg/ml, staining Ezrin / Radixin / Moesin in formalin-fixed, paraffin-embedded Human Breast tissue by Immunohistochemistry.
  • All lanes : Anti-Ezrin / Radixin / Moesin antibody (ab118572) at 1/500 dilution

    Lane 1 : NIH-3T3 cell extract without the synthesized peptide.
    Lane 2 : NIH-3T3 cell extract with the synthesized peptide.


    Predicted band size : 68 kDa

Anti-Ezrin / Radixin / Moesin antibody (ab118572) 使用論文

ab118572 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"