The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 351 kDa. XP_498111
Use at an assay dependent dilution.
Use a concentration of 10 µg/ml.
機能Required to maintain the integrity of photoreceptor cells.
組織特異性Present in retina.
関連疾患Defects in EYS are the cause of retinitis pigmentosa type 25 (RP25) [MIM:602772]. RP leads to degeneration of retinal photoreceptor cells. Patients suffer from night blindness, beginning at approximately 25 years of age, and deterioration of visual acuity (central vision), beginning at approximately 30 years of age. By age 55 to 60 years, many affected subjects have no perception of light in either eye.
配列類似性Belongs to the EYS family. Contains 27 EGF-like domains. Contains 5 laminin G-like domains.
細胞内局在Secreted. Localizes in the photoreceptor cell layer.