製品の概要

  • 製品名Anti-EYA3 antibody
    EYA3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to EYA3
  • アプリケーション適用あり: ICC/IF, IHC-P, IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human EYA3 aa 30-60.
    Database link: Q99504

  • ポジティブ・コントロール
    • HeLa whole cell lysate. IHC controls: Breast Carcinoma, Colon Carcinoma

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab95877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF 1/250 - 1/2000.
IHC-P 1/500 - 1/2000.
IP Use at 2-5 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
    • 配列類似性Belongs to the HAD-like hydrolase superfamily. EYA family.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR. Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX.
    • 細胞内局在Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively.
    • Information by UniProt
    • 参照データベース
    • 別名
      • AI844637 antibody
      • DKFZp686C132 antibody
      • EYA3 antibody
      • EYA3_HUMAN antibody
      • Eyes absent 3 antibody
      • Eyes absent 3 homolog (Drosophila) antibody
      • Eyes absent homolog 3 antibody
      • OTTMUSP00000010370 antibody
      • RP11-460I13.4 antibody
      • RP23-442A20.1 antibody
      see all

    Anti-EYA3 antibody (ab95877) 使用論文

    ab95877 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab95877.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"