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RabMAb

Anti-EYA2 抗体 [EPR2942] (ab92505)

製品の概要

  • 製品名
    Anti-EYA2 antibody [EPR2942]
    EYA2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR2942] to EYA2
  • アプリケーション
    適用あり: WB, IPmore details
    適用なし: Flow Cyt,ICC or IHC-P
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to residues near the N terminal region of Human EYA2 (UniProt ID: O00167).

  • ポジティブ・コントロール
    • Y-79 cell lysate and 293T cell lysate
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab92505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報
    IP: 1/10 - 1/100.
    WB: 1/50000 - 1/200000. Predicted molecular weight: 59 kDa.

    Is unsuitable for Flow Cyt, ICC or IHC.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
    • 組織特異性
      Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
    • 配列類似性
      Belongs to the HAD-like hydrolase superfamily. EYA family.
    • 発生段階
      At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
    • 細胞内局在
      Cytoplasm. Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • EAB 1 antibody
      • EAB1 antibody
      • EYA 2 antibody
      • EYA transcriptional coactivator and phosphatase 2 antibody
      • EYA2 antibody
      • EYA2_HUMAN antibody
      • eyes absent 2 homolog (Drosophila) antibody
      • Eyes absent homolog 2 (Drosophila) antibody
      • Eyes absent homolog 2 antibody
      • Translation of this uORF probably lowers the translation efficiency of EYA2 antibody
      see all

    画像

    • All lanes : Anti-EYA2 antibody [EPR2942] (ab92505) at 1/50000 dilution

      Lane 1 : Y-79 cell lysate
      Lane 2 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP-labeled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 59 kDa

    参考文献

    This product has been referenced in:

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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