製品の概要

  • 製品名Anti-EYA2 antibody
    EYA2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to EYA2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Rabbit, Horse, Cow, Cat, Human, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 200-249 (EAPHNVSQSS ESLAGDYNTH NGPSTPAKEG DTDRPHRASD GKLRGRSKRS) of Rat EYA2 (NP_569111).

  • ポジティブ・コントロール
    • Rat muscle lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab116075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.
  • 組織特異性Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.
  • 配列類似性Belongs to the HAD-like hydrolase superfamily. EYA family.
  • 発生段階At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EAB 1 antibody
    • EAB1 antibody
    • EYA 2 antibody
    • EYA2 antibody
    • EYA2_HUMAN antibody
    • eyes absent 2 homolog (Drosophila) antibody
    • Eyes absent homolog 2 (Drosophila) antibody
    • Eyes absent homolog 2 antibody
    • Translation of this uORF probably lowers the translation efficiency of EYA2 antibody
    see all

Anti-EYA2 antibody 画像

  • Anti-EYA2 antibody (ab116075) at 1 µg/ml + Rat muscle lysate at 10 µg

    Predicted band size : 58 kDa

Anti-EYA2 antibody (ab116075) 使用論文

ab116075 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"